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Image Search Results
Journal: iScience
Article Title: RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathway
doi: 10.1016/j.isci.2026.115734
Figure Lengend Snippet: RIPOR2 is expressed in the melanocytes of an intermediate-grade melanocytic lesion Adjacent sections of an early BRAF V600E -positive intraepidermal melanoma. Dotted boxes are magnified in the adjacent images. (A) H&E stain shows tissue disorganization in the center of the section. (B) Immunohistochemistry with an anti-BRAF V600E antibody stains the mutated melanocytes and highlights the malignant lesion zone. (C) Immunofluorescence with antiSOX10. (D) Anti-RIPOR2 antibodies demonstrated that RIPOR2 is expressed in SOX10+ epidermal nests of BRAF V600E -positive melanocytes, suggesting that it is expressed in malignant melanocytes. The RIPOR2 staining is cytoplasmic. Blue corresponds to Hoechst nuclear staining in all panels. Scale bars, 100 μm.
Article Snippet: 3.5 μm thick paraffine sections were done from samples and staining was done on a Benchmark ULTRA immunohistochemistry automated system (Ventana, Roche Diagnostics), using the
Techniques: Staining, Immunohistochemistry, Immunofluorescence